Entresto is used to treat certain types of heart failure. It will help you live longer and stay out of the hospital for heart failure. Entresto contains 2 medications: sacubitril and valsartan. They work by relaxing blood vessels so that blood can flow more easily, which makes it easier for your heart to pump blood to your body. Common SE: Coughing, dizziness, or lightheadedness, if this persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Take medication as prescribed to get the better manage the disease process of Heart Failure.