SN instructed patient and care giver that Silvadene is used with other treatments to help prevent and treat wound and skin infections. Silver sulfadiazine (silvadene) works by stopping the growth of bacteria. Silver sulfadiazine belongs to a class of drugs known as sulfa antibiotics. Possible SE may include: pain, burning, or itching of the treated skin. Skin and mucous membranes (such as the gums) may become blue/gray in color. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.