SN instructed patient and caregiver about Clonidine, it is used alone or with other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It works by relaxing blood vessels so blood can flow more easily. Possible SE/AR may include: dizziness, lightheadedness, drowsiness, dry mouth, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Tell your doctor right away if you have any serious side effects, including: fainting, slow/irregular heartbeat, mental/mood changes like, irritability, depression.