Patient and CG instructed on Pravastatin. Pravastatin is used to lower cholesterol and triglycerides (types of fat) in the blood. Pravastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with or without coronary heart disease or other risk factors. Pravastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). Get emergency medical help if you have signs of an allergic reaction to pravastatin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, pravastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Stop using and call your doctor at once if you have:unexplained muscle pain, tenderness, or weakness; fever, unusual tiredness; dark colored urine; chest pain; upper stomach pain, loss of appetite; or jaundice (yellowing of the skin or eyes). Common pravastatin side effects may include: muscle or joint pain; nausea, vomiting, diarrhea; headache; or cold symptoms such as stuffy nose, sneezing, sore throat.