SN instructed patient about how the thyroid hormone helps regulate metabolism. When this hormone is abnormally low the energy production decreases, disrupting many vital functions. This can include skin issues such as: Coldness in the fingers and feet with pale and dry coarse skin, eczema, a yellowish hue to the skin, sparse and brittle hair, which comes out in handfuls, loss of hair in the outer third of eyebrows, slow growing, ridged and brittle nails, edema in face, eyelids, hands and feet, and delayed wound healing. Some of these things can be avoided if you are taking your replacement medication daily as ordered and are getting regular blood work to assure the medication is at the correct dose.