SN instructed patient and care giver to take Carafate (sucralfate) on an empty stomach, at least 1 hour before or 2 hours after a meal and avoid taking any other medications within 2 hours before or after you take Carafate. Side effects of Carafate include: nausea, vomiting, GI upset/pain, constipation, diarrhea, insomnia, dizziness, drowsiness or headache.